Drug interactions
Cyproheptadine + Morphine
Severity: Moderate
Cyproheptadine and Morphine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
A sedating antihistamine combined with morphine can increase drowsiness and the risk of respiratory depression. The risk is highest in older, opioid-naive or renally impaired patients.
What this interaction means in plain words
Cyproheptadine and Morphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyproheptadine belongs to Respiratory; Morphine belongs to Musculoskeletal.
Why it happens
Additive CNS and respiratory depression.
What to do
Start with low opioid doses and monitor sedation and respiratory rate. Avoid adding other CNS depressants and counsel on alcohol and driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyproheptadine
- Cyproheptadine + Isocarboxazid Contraindicated
- Cyproheptadine + Phenelzine Contraindicated
- Cyproheptadine + Tranylcypromine Contraindicated
- Alfentanil + Cyproheptadine Major
- Belladonna and opium + Cyproheptadine Major
- Benzhydrocodone / acetaminophen + Cyproheptadine Major
Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Frequently asked questions
Can I take Cyproheptadine with Morphine?
MediHelp rates the interaction as moderate. Cyproheptadine and Morphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. A sedating antihistamine combined with morphine can increase drowsiness and the risk of respiratory depression. The risk is highest in older, opioid-naive or renally impaired patients.
How serious is the interaction between Cyproheptadine and Morphine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with low opioid doses and monitor sedation and respiratory rate. Avoid adding other CNS depressants and counsel on alcohol and driving.
What other medicines interact with Cyproheptadine?
MediHelp also lists interactions of Cyproheptadine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Cyproheptadine page.
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