Drug interactions
Cyproheptadine + Zuranolone
Severity: Moderate
Cyproheptadine and Zuranolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zuranolone causes dose-related somnolence and psychomotor impairment, and cyproheptadine adds sedative effects. The combination may increase drowsiness and impair driving and other tasks.
What this interaction means in plain words
Cyproheptadine and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyproheptadine belongs to Respiratory; Zuranolone belongs to Central Nervous System.
Why it happens
Additive CNS depression from GABA-A positive allosteric modulation and central H1 antagonism.
What to do
Consider a non-sedating alternative to cyproheptadine or reduce the dose of one agent. Advise the patient not to drive or operate machinery while impaired.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyproheptadine
- Cyproheptadine + Isocarboxazid Contraindicated
- Cyproheptadine + Phenelzine Contraindicated
- Cyproheptadine + Tranylcypromine Contraindicated
- Alfentanil + Cyproheptadine Major
- Belladonna and opium + Cyproheptadine Major
- Benzhydrocodone / acetaminophen + Cyproheptadine Major
Other interactions of Zuranolone
- Alprazolam + Zuranolone Major
- Amobarbital + Zuranolone Major
- Apalutamide + Zuranolone Major
- Asenapine + Zuranolone Major
- Brexpiprazole + Zuranolone Major
- Butorphanol + Zuranolone Major
Frequently asked questions
Can I take Cyproheptadine with Zuranolone?
MediHelp rates the interaction as moderate. Cyproheptadine and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zuranolone causes dose-related somnolence and psychomotor impairment, and cyproheptadine adds sedative effects. The combination may increase drowsiness and impair driving and other tasks.
How serious is the interaction between Cyproheptadine and Zuranolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a non-sedating alternative to cyproheptadine or reduce the dose of one agent. Advise the patient not to drive or operate machinery while impaired.
What other medicines interact with Cyproheptadine?
MediHelp also lists interactions of Cyproheptadine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Cyproheptadine page.
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