Drug interactions
Dabigatran + Diflunisal
Severity: Major
Dabigatran and Diflunisal: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diflunisal adds to the bleeding risk of dabigatran through its antiplatelet effect and gastrointestinal mucosal injury. Serious gastrointestinal or other bleeding may result.
What this interaction means in plain words
Dabigatran and Diflunisal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive pharmacodynamic effect on hemostasis through platelet inhibition and mucosal damage combined with thrombin inhibition.
What to do
Avoid regular NSAID use with dabigatran where possible and use paracetamol instead. If necessary, monitor for bleeding signs, hemoglobin and renal function, and consider gastroprotection.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Frequently asked questions
Can I take Dabigatran with Diflunisal?
MediHelp rates the interaction as major. Dabigatran and Diflunisal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Diflunisal adds to the bleeding risk of dabigatran through its antiplatelet effect and gastrointestinal mucosal injury. Serious gastrointestinal or other bleeding may result.
How serious is the interaction between Dabigatran and Diflunisal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular NSAID use with dabigatran where possible and use paracetamol instead. If necessary, monitor for bleeding signs, hemoglobin and renal function, and consider gastroprotection.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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