Drug interactions
Dabigatran + Imatinib
Severity: Moderate
Dabigatran and Imatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib can cause thrombocytopenia and may add to the bleeding risk of dabigatran, which is an anticoagulant. Imatinib may also affect P-glycoprotein, potentially raising dabigatran exposure.
What this interaction means in plain words
Dabigatran and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive bleeding risk from imatinib-induced cytopenias plus anticoagulation, with possible P-gp inhibition raising dabigatran levels.
What to do
Monitor the platelet count and renal function and watch for bleeding. Consider holding or switching the anticoagulant if thrombocytopenia becomes significant.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Dabigatran with Imatinib?
MediHelp rates the interaction as moderate. Dabigatran and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib can cause thrombocytopenia and may add to the bleeding risk of dabigatran, which is an anticoagulant. Imatinib may also affect P-glycoprotein, potentially raising dabigatran exposure.
How serious is the interaction between Dabigatran and Imatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the platelet count and renal function and watch for bleeding. Consider holding or switching the anticoagulant if thrombocytopenia becomes significant.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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