Drug interactions
Dabigatran + Ketoprofen
Severity: Major
Dabigatran and Ketoprofen: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabigatran is an anticoagulant, and ketoprofen impairs platelet function and can cause gastrointestinal lesions, so concurrent use increases the risk of clinically significant bleeding.
What this interaction means in plain words
Dabigatran and Ketoprofen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive effects on hemostasis: direct thrombin inhibition plus NSAID antiplatelet activity and mucosal injury.
What to do
Avoid regular NSAID use with dabigatran; use paracetamol where possible. If unavoidable, use the lowest NSAID dose briefly, consider gastroprotection and monitor for bleeding.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Frequently asked questions
Can I take Dabigatran with Ketoprofen?
MediHelp rates the interaction as major. Dabigatran and Ketoprofen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dabigatran is an anticoagulant, and ketoprofen impairs platelet function and can cause gastrointestinal lesions, so concurrent use increases the risk of clinically significant bleeding.
How serious is the interaction between Dabigatran and Ketoprofen?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular NSAID use with dabigatran; use paracetamol where possible. If unavoidable, use the lowest NSAID dose briefly, consider gastroprotection and monitor for bleeding.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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