Drug interactions
Dabigatran + Lapatinib
Severity: Moderate
Dabigatran and Lapatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib inhibits P-glycoprotein, which can increase absorption of dabigatran etexilate and raise dabigatran exposure. This increases bleeding risk, particularly in patients with renal impairment.
What this interaction means in plain words
Dabigatran and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Lapatinib inhibits intestinal P-glycoprotein efflux of dabigatran etexilate.
What to do
Monitor for bleeding and assess renal function. Avoid the combination in patients with significant renal impairment, per dabigatran labeling thresholds, or consider another anticoagulant.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Dabigatran with Lapatinib?
MediHelp rates the interaction as moderate. Dabigatran and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lapatinib inhibits P-glycoprotein, which can increase absorption of dabigatran etexilate and raise dabigatran exposure. This increases bleeding risk, particularly in patients with renal impairment.
How serious is the interaction between Dabigatran and Lapatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and assess renal function. Avoid the combination in patients with significant renal impairment, per dabigatran labeling thresholds, or consider another anticoagulant.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
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