Drug interactions
Dabigatran + Mifepristone
Severity: Major
Dabigatran and Mifepristone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone abortion causes uterine bleeding that may be heavy, and dabigatran anticoagulation can worsen it. Dabigatran is also a P-gp substrate, and mifepristone may inhibit P-gp.
What this interaction means in plain words
Dabigatran and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive anticoagulant effect on bleeding, and possible P-gp inhibition raising dabigatran levels.
What to do
Avoid unless anticoagulation is essential. If needed, plan timing with specialist input and monitor bleeding and hemoglobin.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Dabigatran with Mifepristone?
MediHelp rates the interaction as major. Dabigatran and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mifepristone abortion causes uterine bleeding that may be heavy, and dabigatran anticoagulation can worsen it. Dabigatran is also a P-gp substrate, and mifepristone may inhibit P-gp.
How serious is the interaction between Dabigatran and Mifepristone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unless anticoagulation is essential. If needed, plan timing with specialist input and monitor bleeding and hemoglobin.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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