Drug interactions
Dabigatran + Nicardipine
Severity: Moderate
Dabigatran and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine may modestly increase dabigatran exposure by inhibiting P-glycoprotein-mediated efflux of dabigatran etexilate. Higher dabigatran levels raise bleeding risk, particularly in patients with reduced renal function.
What this interaction means in plain words
Dabigatran and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of intestinal P-glycoprotein by nicardipine increases absorption of dabigatran etexilate.
What to do
Assess renal function and follow labeled dabigatran restrictions with P-gp inhibitors, avoiding the combination in severe renal impairment. Monitor for signs of bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Frequently asked questions
Can I take Dabigatran with Nicardipine?
MediHelp rates the interaction as moderate. Dabigatran and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nicardipine may modestly increase dabigatran exposure by inhibiting P-glycoprotein-mediated efflux of dabigatran etexilate. Higher dabigatran levels raise bleeding risk, particularly in patients with reduced renal function.
How serious is the interaction between Dabigatran and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess renal function and follow labeled dabigatran restrictions with P-gp inhibitors, avoiding the combination in severe renal impairment. Monitor for signs of bleeding.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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