Drug interactions
Dabigatran + Propafenone
Severity: Moderate
Dabigatran and Propafenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propafenone inhibits P-glycoprotein and can increase dabigatran plasma concentrations. Higher exposure raises bleeding risk, especially in patients with reduced renal function.
What this interaction means in plain words
Dabigatran and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of intestinal and renal P-glycoprotein efflux of dabigatran by propafenone.
What to do
Monitor for bleeding and check renal function regularly. Follow dabigatran labeling and avoid the combination in patients with significant renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Frequently asked questions
Can I take Dabigatran with Propafenone?
MediHelp rates the interaction as moderate. Dabigatran and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propafenone inhibits P-glycoprotein and can increase dabigatran plasma concentrations. Higher exposure raises bleeding risk, especially in patients with reduced renal function.
How serious is the interaction between Dabigatran and Propafenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and check renal function regularly. Follow dabigatran labeling and avoid the combination in patients with significant renal impairment.
What other medicines interact with Propafenone?
MediHelp also lists interactions of Propafenone with, for example, Dofetilide, Dronedarone, Nilotinib. The full list is on the Propafenone page.
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