Drug interactions
Dabigatran + Vinblastine
Severity: Minor
Dabigatran and Vinblastine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vinblastine is a P-glycoprotein substrate and is not an established P-gp inducer, so a clinically significant reduction in dabigatran exposure is not well supported. The listed interaction is largely theoretical.
What this interaction means in plain words
Dabigatran and Vinblastine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
A P-gp effect has been proposed but is not established.
What to do
No routine change is needed. Monitor for thrombotic or bleeding events, particularly given chemotherapy-related thrombocytopenia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Vinblastine
Frequently asked questions
Can I take Dabigatran with Vinblastine?
MediHelp rates the interaction as minor. Dabigatran and Vinblastine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vinblastine is a P-glycoprotein substrate and is not an established P-gp inducer, so a clinically significant reduction in dabigatran exposure is not well supported. The listed interaction is largely theoretical.
How serious is the interaction between Dabigatran and Vinblastine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Monitor for thrombotic or bleeding events, particularly given chemotherapy-related thrombocytopenia.
What other medicines interact with Vinblastine?
MediHelp also lists interactions of Vinblastine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vinblastine page.
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