Drug interactions
Dabigatran etexilate + Dipyridamole
Severity: Moderate
Dabigatran etexilate and Dipyridamole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dipyridamole inhibits platelet aggregation, so combining it with dabigatran increases bleeding risk. It also inhibits P-glycoprotein in vitro, which could add a small increase in dabigatran exposure.
What this interaction means in plain words
Dabigatran etexilate and Dipyridamole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabigatran etexilate belongs to Cardiovascular; Dipyridamole belongs to Cardiovascular.
Why it happens
Additive antiplatelet and anticoagulant effects, with possible weak P-glycoprotein inhibition.
What to do
Monitor for bleeding and renal function. Reassess the need for dual therapy periodically.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dabigatran etexilate
- Dabigatran etexilate + Defibrotide Contraindicated
- Dabigatran etexilate + Ketorolac Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
- Abciximab + Dabigatran etexilate Major
- Alteplase + Dabigatran etexilate Major
- Amiodarone + Dabigatran etexilate Major
Other interactions of Dipyridamole
- Dipyridamole + Riociguat Contraindicated
- Adenosine + Dipyridamole Major
- Betrixaban + Dipyridamole Major
- Dabigatran + Dipyridamole Major
- Dipyridamole + Regadenoson Major
- Dipyridamole + Venetoclax Major
Frequently asked questions
Can I take Dabigatran etexilate with Dipyridamole?
MediHelp rates the interaction as moderate. Dabigatran etexilate and Dipyridamole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dipyridamole inhibits platelet aggregation, so combining it with dabigatran increases bleeding risk. It also inhibits P-glycoprotein in vitro, which could add a small increase in dabigatran exposure.
How serious is the interaction between Dabigatran etexilate and Dipyridamole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and renal function. Reassess the need for dual therapy periodically.
What other medicines interact with Dabigatran etexilate?
MediHelp also lists interactions of Dabigatran etexilate with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dabigatran etexilate page.
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