Drug interactions
Dabigatran etexilate + Epoprostenol
Severity: Moderate
Dabigatran etexilate and Epoprostenol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epoprostenol inhibits platelet aggregation, so combining it with an anticoagulant such as dabigatran adds to bleeding tendency. The clinical risk is greatest in patients with other bleeding risk factors.
What this interaction means in plain words
Dabigatran etexilate and Epoprostenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabigatran etexilate belongs to Cardiovascular; Epoprostenol belongs to Genitourinary.
Why it happens
Additive pharmacodynamic effect: platelet inhibition by epoprostenol plus thrombin inhibition by dabigatran.
What to do
Monitor for signs of bleeding and check hemoglobin periodically. Reassess the need for both drugs if bleeding occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dabigatran etexilate
- Dabigatran etexilate + Defibrotide Contraindicated
- Dabigatran etexilate + Ketorolac Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
- Abciximab + Dabigatran etexilate Major
- Alteplase + Dabigatran etexilate Major
- Amiodarone + Dabigatran etexilate Major
Other interactions of Epoprostenol
- Acetylsalicylic acid + Epoprostenol Moderate
- Aescin + Epoprostenol Moderate
- Aldesleukin + Epoprostenol Moderate
- Alteplase + Epoprostenol Moderate
- Amlodipine-benazepril + Epoprostenol Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Epoprostenol Moderate
Frequently asked questions
Can I take Dabigatran etexilate with Epoprostenol?
MediHelp rates the interaction as moderate. Dabigatran etexilate and Epoprostenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epoprostenol inhibits platelet aggregation, so combining it with an anticoagulant such as dabigatran adds to bleeding tendency. The clinical risk is greatest in patients with other bleeding risk factors.
How serious is the interaction between Dabigatran etexilate and Epoprostenol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding and check hemoglobin periodically. Reassess the need for both drugs if bleeding occurs.
What other medicines interact with Dabigatran etexilate?
MediHelp also lists interactions of Dabigatran etexilate with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dabigatran etexilate page.
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