Drug interactions
Dabigatran etexilate + Flurbiprofen
Severity: Moderate
Dabigatran etexilate and Flurbiprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flurbiprofen inhibits platelet function and can injure the gastric mucosa, which raises the risk of gastrointestinal and other bleeding in patients taking dabigatran. The risk is higher in older patients, in renal impairment, and with prolonged NSAID use.
What this interaction means in plain words
Dabigatran etexilate and Flurbiprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabigatran etexilate belongs to Cardiovascular; Flurbiprofen belongs to Musculoskeletal.
Why it happens
Additive effect on hemostasis: NSAID-mediated COX-1 platelet inhibition and mucosal injury combined with direct thrombin inhibition.
What to do
Avoid the NSAID where possible and use paracetamol or another alternative. If required, use the lowest dose for the shortest time, consider gastroprotection and monitor for bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dabigatran etexilate
- Dabigatran etexilate + Defibrotide Contraindicated
- Dabigatran etexilate + Ketorolac Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
- Abciximab + Dabigatran etexilate Major
- Alteplase + Dabigatran etexilate Major
- Amiodarone + Dabigatran etexilate Major
Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Frequently asked questions
Can I take Dabigatran etexilate with Flurbiprofen?
MediHelp rates the interaction as moderate. Dabigatran etexilate and Flurbiprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Flurbiprofen inhibits platelet function and can injure the gastric mucosa, which raises the risk of gastrointestinal and other bleeding in patients taking dabigatran. The risk is higher in older patients, in renal impairment, and with prolonged NSAID use.
How serious is the interaction between Dabigatran etexilate and Flurbiprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the NSAID where possible and use paracetamol or another alternative. If required, use the lowest dose for the shortest time, consider gastroprotection and monitor for bleeding.
What other medicines interact with Dabigatran etexilate?
MediHelp also lists interactions of Dabigatran etexilate with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dabigatran etexilate page.
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