Drug interactions
Dabigatran etexilate + Ibrutinib
Severity: Major
Dabigatran etexilate and Ibrutinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibrutinib inhibits platelet function and is associated with bleeding, and it can inhibit intestinal P-glycoprotein, which may increase dabigatran exposure. Together these effects raise the risk of clinically significant hemorrhage, especially with reduced renal function.
What this interaction means in plain words
Dabigatran etexilate and Ibrutinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dabigatran etexilate belongs to Cardiovascular; Ibrutinib belongs to Oncology.
Why it happens
Additive antiplatelet and anticoagulant effects, plus P-glycoprotein inhibition by ibrutinib that may raise dabigatran absorption.
What to do
Avoid the combination where possible, particularly with reduced creatinine clearance. If used, monitor closely for bleeding and renal function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dabigatran etexilate
- Dabigatran etexilate + Defibrotide Contraindicated
- Dabigatran etexilate + Ketorolac Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
- Abciximab + Dabigatran etexilate Major
- Alteplase + Dabigatran etexilate Major
- Amiodarone + Dabigatran etexilate Major
Other interactions of Ibrutinib
- Abciximab + Ibrutinib Major
- Acetylsalicylic acid + Ibrutinib Major
- Alteplase + Ibrutinib Major
- Amobarbital + Ibrutinib Major
- Apalutamide + Ibrutinib Major
- Apixaban + Ibrutinib Major
Frequently asked questions
Can I take Dabigatran etexilate with Ibrutinib?
MediHelp rates the interaction as major. Dabigatran etexilate and Ibrutinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ibrutinib inhibits platelet function and is associated with bleeding, and it can inhibit intestinal P-glycoprotein, which may increase dabigatran exposure. Together these effects raise the risk of clinically significant hemorrhage, especially with reduced renal function.
How serious is the interaction between Dabigatran etexilate and Ibrutinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, particularly with reduced creatinine clearance. If used, monitor closely for bleeding and renal function.
What other medicines interact with Dabigatran etexilate?
MediHelp also lists interactions of Dabigatran etexilate with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dabigatran etexilate page.
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