Drug interactions
Dabigatran etexilate + Istradefylline
Severity: Moderate
Dabigatran etexilate and Istradefylline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Istradefylline at higher doses increased exposure to P-glycoprotein substrates, so dabigatran levels may rise. This could increase bleeding risk.
What this interaction means in plain words
Dabigatran etexilate and Istradefylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabigatran etexilate belongs to Cardiovascular; Istradefylline belongs to Central Nervous System.
Why it happens
Istradefylline inhibits P-glycoprotein, increasing dabigatran etexilate absorption.
What to do
Monitor for bleeding and renal function; consider a lower dabigatran dose if istradefylline 40 mg/day is used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dabigatran etexilate
- Dabigatran etexilate + Defibrotide Contraindicated
- Dabigatran etexilate + Ketorolac Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
- Abciximab + Dabigatran etexilate Major
- Alteplase + Dabigatran etexilate Major
- Amiodarone + Dabigatran etexilate Major
Other interactions of Istradefylline
Frequently asked questions
Can I take Dabigatran etexilate with Istradefylline?
MediHelp rates the interaction as moderate. Dabigatran etexilate and Istradefylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Istradefylline at higher doses increased exposure to P-glycoprotein substrates, so dabigatran levels may rise. This could increase bleeding risk.
How serious is the interaction between Dabigatran etexilate and Istradefylline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and renal function; consider a lower dabigatran dose if istradefylline 40 mg/day is used.
What other medicines interact with Dabigatran etexilate?
MediHelp also lists interactions of Dabigatran etexilate with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dabigatran etexilate page.
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