Drug interactions
Dabigatran etexilate + Meloxicam
Severity: Moderate
Dabigatran etexilate and Meloxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meloxicam can impair platelet function and irritate the gastrointestinal tract, increasing bleeding risk when combined with dabigatran. Although somewhat COX-2 preferential, meaningful bleeding risk remains.
What this interaction means in plain words
Dabigatran etexilate and Meloxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabigatran etexilate belongs to Cardiovascular; Meloxicam belongs to Musculoskeletal.
Why it happens
Additive effect on hemostasis: NSAID antiplatelet effect and mucosal injury with thrombin inhibition.
What to do
Use non-NSAID analgesia if possible. If needed, use the lowest dose for the shortest time and monitor for bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dabigatran etexilate
- Dabigatran etexilate + Defibrotide Contraindicated
- Dabigatran etexilate + Ketorolac Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
- Abciximab + Dabigatran etexilate Major
- Alteplase + Dabigatran etexilate Major
- Amiodarone + Dabigatran etexilate Major
Other interactions of Meloxicam
- Ketorolac intranasal + Meloxicam Contraindicated
- Ketorolac + Meloxicam Contraindicated
- Aceclofenac + Meloxicam Major
- Acemetacin + Meloxicam Major
- Acetylsalicylic acid + Meloxicam Major
- Alteplase + Meloxicam Major
Frequently asked questions
Can I take Dabigatran etexilate with Meloxicam?
MediHelp rates the interaction as moderate. Dabigatran etexilate and Meloxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meloxicam can impair platelet function and irritate the gastrointestinal tract, increasing bleeding risk when combined with dabigatran. Although somewhat COX-2 preferential, meaningful bleeding risk remains.
How serious is the interaction between Dabigatran etexilate and Meloxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use non-NSAID analgesia if possible. If needed, use the lowest dose for the shortest time and monitor for bleeding.
What other medicines interact with Dabigatran etexilate?
MediHelp also lists interactions of Dabigatran etexilate with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dabigatran etexilate page.
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