Drug interactions
Dabigatran etexilate + Naproxen
Severity: Moderate
Dabigatran etexilate and Naproxen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Naproxen inhibits platelet aggregation and can cause gastrointestinal ulceration and bleeding, which adds to the hemorrhagic risk of dabigatran. Risk is increased in elderly patients and with renal impairment.
What this interaction means in plain words
Dabigatran etexilate and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabigatran etexilate belongs to Cardiovascular; Naproxen belongs to Musculoskeletal.
Why it happens
Additive effect on hemostasis: NSAID platelet inhibition and mucosal injury with thrombin inhibition.
What to do
Avoid where possible and use paracetamol instead. If required, use the shortest course, consider gastroprotection and monitor for bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dabigatran etexilate
- Dabigatran etexilate + Defibrotide Contraindicated
- Dabigatran etexilate + Ketorolac Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
- Abciximab + Dabigatran etexilate Major
- Alteplase + Dabigatran etexilate Major
- Amiodarone + Dabigatran etexilate Major
Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Frequently asked questions
Can I take Dabigatran etexilate with Naproxen?
MediHelp rates the interaction as moderate. Dabigatran etexilate and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Naproxen inhibits platelet aggregation and can cause gastrointestinal ulceration and bleeding, which adds to the hemorrhagic risk of dabigatran. Risk is increased in elderly patients and with renal impairment.
How serious is the interaction between Dabigatran etexilate and Naproxen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid where possible and use paracetamol instead. If required, use the shortest course, consider gastroprotection and monitor for bleeding.
What other medicines interact with Dabigatran etexilate?
MediHelp also lists interactions of Dabigatran etexilate with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dabigatran etexilate page.
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