Drug interactions
Dabigatran etexilate + Nifedipine
Severity: Minor
Dabigatran etexilate and Nifedipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nifedipine has weak P-glycoprotein inhibitory activity and any rise in dabigatran exposure is likely small. Clinical significance is limited in patients with normal renal function.
What this interaction means in plain words
Dabigatran etexilate and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dabigatran etexilate belongs to Cardiovascular; Nifedipine belongs to Cardiovascular.
Why it happens
Weak inhibition of P-glycoprotein efflux of dabigatran etexilate.
What to do
No routine adjustment is needed; be aware in patients with renal impairment and monitor for bleeding.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dabigatran etexilate
- Dabigatran etexilate + Defibrotide Contraindicated
- Dabigatran etexilate + Ketorolac Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
- Abciximab + Dabigatran etexilate Major
- Alteplase + Dabigatran etexilate Major
- Amiodarone + Dabigatran etexilate Major
Other interactions of Nifedipine
Frequently asked questions
Can I take Dabigatran etexilate with Nifedipine?
MediHelp rates the interaction as minor. Dabigatran etexilate and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nifedipine has weak P-glycoprotein inhibitory activity and any rise in dabigatran exposure is likely small. Clinical significance is limited in patients with normal renal function.
How serious is the interaction between Dabigatran etexilate and Nifedipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; be aware in patients with renal impairment and monitor for bleeding.
What other medicines interact with Dabigatran etexilate?
MediHelp also lists interactions of Dabigatran etexilate with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dabigatran etexilate page.
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