Drug interactions
Dabigatran etexilate + Rifabutin
Severity: Moderate
Dabigatran etexilate and Rifabutin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifabutin can reduce dabigatran plasma concentrations, which may lead to inadequate anticoagulation and thromboembolic events. Rifabutin is a weaker inducer than rifampin, but the effect is still relevant.
What this interaction means in plain words
Dabigatran etexilate and Rifabutin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabigatran etexilate belongs to Cardiovascular; Rifabutin belongs to Anti Bacterial.
Why it happens
Rifabutin induces intestinal P-glycoprotein, decreasing dabigatran etexilate absorption.
What to do
Avoid concomitant use where possible and consider an alternative anticoagulant or antimycobacterial agent. If unavoidable, monitor for signs of thromboembolism.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dabigatran etexilate
- Dabigatran etexilate + Defibrotide Contraindicated
- Dabigatran etexilate + Ketorolac Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
- Abciximab + Dabigatran etexilate Major
- Alteplase + Dabigatran etexilate Major
- Amiodarone + Dabigatran etexilate Major
Other interactions of Rifabutin
- Cabotegravir + Rifabutin Contraindicated
- Lorlatinib + Rifabutin Contraindicated
- Rifabutin + Voriconazole Contraindicated
- Apixaban + Rifabutin Major
- Axitinib + Rifabutin Major
- Brexpiprazole + Rifabutin Major
Frequently asked questions
Can I take Dabigatran etexilate with Rifabutin?
MediHelp rates the interaction as moderate. Dabigatran etexilate and Rifabutin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifabutin can reduce dabigatran plasma concentrations, which may lead to inadequate anticoagulation and thromboembolic events. Rifabutin is a weaker inducer than rifampin, but the effect is still relevant.
How serious is the interaction between Dabigatran etexilate and Rifabutin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use where possible and consider an alternative anticoagulant or antimycobacterial agent. If unavoidable, monitor for signs of thromboembolism.
What other medicines interact with Dabigatran etexilate?
MediHelp also lists interactions of Dabigatran etexilate with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dabigatran etexilate page.
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