Drug interactions
Dabigatran etexilate + Tirofiban
Severity: Major
Dabigatran etexilate and Tirofiban: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tirofiban is a potent intravenous antiplatelet agent and combined with dabigatran markedly increases the risk of bleeding. Use is generally limited to acute coronary settings in which bleeding risk must be actively managed.
What this interaction means in plain words
Dabigatran etexilate and Tirofiban can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dabigatran etexilate belongs to Cardiovascular; Tirofiban belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic effect: glycoprotein IIb/IIIa receptor blockade with direct thrombin inhibition.
What to do
Avoid overlap where possible, and time dabigatran dosing around tirofiban infusion per the clinical protocol. Monitor for bleeding and hemoglobin.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dabigatran etexilate
- Dabigatran etexilate + Defibrotide Contraindicated
- Dabigatran etexilate + Ketorolac Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
- Abciximab + Dabigatran etexilate Major
- Alteplase + Dabigatran etexilate Major
- Amiodarone + Dabigatran etexilate Major
Other interactions of Tirofiban
Frequently asked questions
Can I take Dabigatran etexilate with Tirofiban?
MediHelp rates the interaction as major. Dabigatran etexilate and Tirofiban can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tirofiban is a potent intravenous antiplatelet agent and combined with dabigatran markedly increases the risk of bleeding. Use is generally limited to acute coronary settings in which bleeding risk must be actively managed.
How serious is the interaction between Dabigatran etexilate and Tirofiban?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid overlap where possible, and time dabigatran dosing around tirofiban infusion per the clinical protocol. Monitor for bleeding and hemoglobin.
What other medicines interact with Dabigatran etexilate?
MediHelp also lists interactions of Dabigatran etexilate with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dabigatran etexilate page.
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