Drug interactions
Dabigatran etexilate + Tolmetin
Severity: Moderate
Dabigatran etexilate and Tolmetin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tolmetin, an NSAID, impairs platelet function and can injure gastric mucosa, so using it with dabigatran increases bleeding risk, especially gastrointestinal bleeding.
What this interaction means in plain words
Dabigatran etexilate and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabigatran etexilate belongs to Cardiovascular; Tolmetin belongs to Musculoskeletal.
Why it happens
Additive hemostatic impairment: thrombin inhibition by dabigatran and platelet cyclooxygenase inhibition by tolmetin.
What to do
Prefer a non-NSAID analgesic such as paracetamol. If an NSAID is necessary, use the lowest effective dose briefly and monitor for bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dabigatran etexilate
- Dabigatran etexilate + Defibrotide Contraindicated
- Dabigatran etexilate + Ketorolac Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
- Abciximab + Dabigatran etexilate Major
- Alteplase + Dabigatran etexilate Major
- Amiodarone + Dabigatran etexilate Major
Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Frequently asked questions
Can I take Dabigatran etexilate with Tolmetin?
MediHelp rates the interaction as moderate. Dabigatran etexilate and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tolmetin, an NSAID, impairs platelet function and can injure gastric mucosa, so using it with dabigatran increases bleeding risk, especially gastrointestinal bleeding.
How serious is the interaction between Dabigatran etexilate and Tolmetin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-NSAID analgesic such as paracetamol. If an NSAID is necessary, use the lowest effective dose briefly and monitor for bleeding.
What other medicines interact with Dabigatran etexilate?
MediHelp also lists interactions of Dabigatran etexilate with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dabigatran etexilate page.
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