Drug interactions
Dabrafenib + Dapagliflozin-metformin
Severity: Minor
Dabrafenib and Dapagliflozin-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib can induce hyperglycemia in some patients, which may offset the glucose-lowering effect of the dapagliflozin-metformin combination. Glycemic control may deteriorate during therapy.
What this interaction means in plain words
Dabrafenib and Dapagliflozin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dabrafenib belongs to Oncology; Dapagliflozin-metformin belongs to Endocrine.
Why it happens
Dabrafenib is associated with hyperglycemia through an incompletely defined pharmacodynamic effect, and it also induces CYP enzymes, though the clinical effect on metformin is not established.
What to do
Monitor blood glucose and HbA1c after dabrafenib is started or stopped. Adjust antidiabetic therapy if glycemic control changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dabrafenib and Dapagliflozin-metformin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Dapagliflozin-metformin
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Dapagliflozin-metformin?
MediHelp rates the interaction as minor. Dabrafenib and Dapagliflozin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dabrafenib can induce hyperglycemia in some patients, which may offset the glucose-lowering effect of the dapagliflozin-metformin combination. Glycemic control may deteriorate during therapy.
How serious is the interaction between Dabrafenib and Dapagliflozin-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after dabrafenib is started or stopped. Adjust antidiabetic therapy if glycemic control changes.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
