Drug interactions
Dabrafenib + Dexlansoprazole
Severity: Minor
Dabrafenib and Dexlansoprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib solubility falls as pH rises, so acid suppression may reduce its absorption. Studies with acid reducers suggested no clinically important change in exposure.
What this interaction means in plain words
Dabrafenib and Dexlansoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dabrafenib belongs to Oncology; Dexlansoprazole belongs to Gastrointestinal Tract.
Why it happens
Higher gastric pH may reduce dabrafenib dissolution.
What to do
No dose adjustment is required. Monitor treatment response if the PPI is started or stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dexlansoprazole
- Dexlansoprazole + Mavacamten Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Dexlansoprazole Major
- Atazanavir + Dexlansoprazole Major
- Dacomitinib + Dexlansoprazole Major
- Dasatinib + Dexlansoprazole Major
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Dexlansoprazole?
MediHelp rates the interaction as minor. Dabrafenib and Dexlansoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dabrafenib solubility falls as pH rises, so acid suppression may reduce its absorption. Studies with acid reducers suggested no clinically important change in exposure.
How serious is the interaction between Dabrafenib and Dexlansoprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is required. Monitor treatment response if the PPI is started or stopped.
What other medicines interact with Dexlansoprazole?
MediHelp also lists interactions of Dexlansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Dexlansoprazole page.
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