Drug interactions
Dabrafenib + Famotidine
Severity: Moderate
Dabrafenib and Famotidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib capsules dissolve less well at higher gastric pH, so acid suppression with famotidine may lower its absorption. Reduced exposure could weaken antitumour activity, although the clinical consequence has not been firmly established.
What this interaction means in plain words
Dabrafenib and Famotidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabrafenib belongs to Oncology; Famotidine belongs to Gastrointestinal Tract.
Why it happens
Raised gastric pH reduces the pH-dependent solubility and oral bioavailability of dabrafenib.
What to do
Monitor for loss of tumour response when acid suppression is needed, and review the need for the H2 blocker. Consider avoiding long-term acid suppression where an alternative is possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Famotidine
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Famotidine?
MediHelp rates the interaction as moderate. Dabrafenib and Famotidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib capsules dissolve less well at higher gastric pH, so acid suppression with famotidine may lower its absorption. Reduced exposure could weaken antitumour activity, although the clinical consequence has not been firmly established.
How serious is the interaction between Dabrafenib and Famotidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of tumour response when acid suppression is needed, and review the need for the H2 blocker. Consider avoiding long-term acid suppression where an alternative is possible.
What other medicines interact with Famotidine?
MediHelp also lists interactions of Famotidine with, for example, Atazanavir, Dasatinib, Infigratinib. The full list is on the Famotidine page.
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