Drug interactions
Dabrafenib + Felodipine
Severity: Moderate
Dabrafenib and Felodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and may substantially reduce felodipine exposure, which is highly dependent on CYP3A4 metabolism. Blood pressure control may be lost.
What this interaction means in plain words
Dabrafenib and Felodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabrafenib belongs to Oncology; Felodipine belongs to Cardiovascular.
Why it happens
Induction of CYP3A4 by dabrafenib increases felodipine metabolism.
What to do
Monitor blood pressure and increase the felodipine dose if needed, or use an alternative antihypertensive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Felodipine?
MediHelp rates the interaction as moderate. Dabrafenib and Felodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib induces CYP3A4 and may substantially reduce felodipine exposure, which is highly dependent on CYP3A4 metabolism. Blood pressure control may be lost.
How serious is the interaction between Dabrafenib and Felodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and increase the felodipine dose if needed, or use an alternative antihypertensive.
What other medicines interact with Felodipine?
MediHelp also lists interactions of Felodipine with, for example, Itraconazole, Aldesleukin, Amifostine. The full list is on the Felodipine page.
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