Drug interactions
Dabrafenib + Flutamide
Severity: Minor
Dabrafenib and Flutamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and other enzymes and may reduce flutamide exposure. Reduced antiandrogen effect is possible but has not been well documented.
What this interaction means in plain words
Dabrafenib and Flutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dabrafenib belongs to Oncology; Flutamide belongs to Endocrine.
Why it happens
Dabrafenib induces CYP3A4, increasing flutamide clearance.
What to do
Monitor PSA and clinical response to antiandrogen therapy during coadministration. Consider an alternative if efficacy is lost.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Flutamide
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Flutamide?
MediHelp rates the interaction as minor. Dabrafenib and Flutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dabrafenib induces CYP3A4 and other enzymes and may reduce flutamide exposure. Reduced antiandrogen effect is possible but has not been well documented.
How serious is the interaction between Dabrafenib and Flutamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor PSA and clinical response to antiandrogen therapy during coadministration. Consider an alternative if efficacy is lost.
What other medicines interact with Flutamide?
MediHelp also lists interactions of Flutamide with, for example, Idelalisib, Levoketoconazole, Pexidartinib. The full list is on the Flutamide page.
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