Drug interactions
Dabrafenib + Fluticasone-vilanterol
Severity: Minor
Dabrafenib and Fluticasone-vilanterol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and may lower exposure to fluticasone furoate and vilanterol. This could reduce asthma or COPD control, although the clinical effect of the inhaled products is uncertain.
What this interaction means in plain words
Dabrafenib and Fluticasone-vilanterol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dabrafenib belongs to Oncology; Fluticasone-vilanterol belongs to Respiratory.
Why it happens
Induction of CYP3A4 increases metabolism of fluticasone furoate and vilanterol.
What to do
Monitor respiratory symptom control and consider adjusting therapy if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluticasone-vilanterol
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Fluticasone-vilanterol?
MediHelp rates the interaction as minor. Dabrafenib and Fluticasone-vilanterol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dabrafenib induces CYP3A4 and may lower exposure to fluticasone furoate and vilanterol. This could reduce asthma or COPD control, although the clinical effect of the inhaled products is uncertain.
How serious is the interaction between Dabrafenib and Fluticasone-vilanterol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor respiratory symptom control and consider adjusting therapy if control worsens.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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