Drug interactions
Dabrafenib + Hydrochlorothiazide-losartan
Severity: Minor
Dabrafenib and Hydrochlorothiazide-losartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces drug-metabolizing enzymes and may lower losartan levels and its active metabolite. This could weaken blood pressure control.
What this interaction means in plain words
Dabrafenib and Hydrochlorothiazide-losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dabrafenib belongs to Oncology; Hydrochlorothiazide-losartan belongs to Cardiovascular.
Why it happens
Dabrafenib induction of CYP3A4 and CYP2C9 increasing losartan metabolism.
What to do
Monitor blood pressure during dabrafenib therapy and adjust losartan dose or add antihypertensives if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Hydrochlorothiazide-losartan?
MediHelp rates the interaction as minor. Dabrafenib and Hydrochlorothiazide-losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dabrafenib induces drug-metabolizing enzymes and may lower losartan levels and its active metabolite. This could weaken blood pressure control.
How serious is the interaction between Dabrafenib and Hydrochlorothiazide-losartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during dabrafenib therapy and adjust losartan dose or add antihypertensives if needed.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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