Drug interactions
Dabrafenib + Lapatinib
Severity: Moderate
Dabrafenib and Lapatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and may lower lapatinib exposure, potentially reducing its efficacy.
What this interaction means in plain words
Dabrafenib and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabrafenib belongs to Oncology; Lapatinib belongs to Oncology.
Why it happens
Induction of CYP3A4 by dabrafenib increases lapatinib clearance.
What to do
Avoid combination where possible; if needed, consider titrating lapatinib dose upward as labeled for CYP3A4 inducers. Monitor for loss of response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Lapatinib?
MediHelp rates the interaction as moderate. Dabrafenib and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib induces CYP3A4 and may lower lapatinib exposure, potentially reducing its efficacy.
How serious is the interaction between Dabrafenib and Lapatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combination where possible; if needed, consider titrating lapatinib dose upward as labeled for CYP3A4 inducers. Monitor for loss of response.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
Full monographs, dosing and an interaction checker in the MediHelp app
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