Drug interactions
Dabrafenib + Metaxalone
Severity: Minor
Dabrafenib and Metaxalone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib is an inducer of CYP3A4 and other enzymes. It may lower metaxalone exposure and reduce its effectiveness, although the clinical effect is probably small.
What this interaction means in plain words
Dabrafenib and Metaxalone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dabrafenib belongs to Oncology; Metaxalone belongs to Musculoskeletal.
Why it happens
Dabrafenib induces CYP3A4 and increases metaxalone metabolism.
What to do
Monitor for reduced muscle relaxant response during dabrafenib therapy. Consider a different muscle relaxant if the response is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metaxalone
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Metaxalone?
MediHelp rates the interaction as minor. Dabrafenib and Metaxalone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dabrafenib is an inducer of CYP3A4 and other enzymes. It may lower metaxalone exposure and reduce its effectiveness, although the clinical effect is probably small.
How serious is the interaction between Dabrafenib and Metaxalone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced muscle relaxant response during dabrafenib therapy. Consider a different muscle relaxant if the response is inadequate.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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