Drug interactions
Dabrafenib + Mifepristone
Severity: Moderate
Dabrafenib and Mifepristone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib is metabolized by CYP3A4 and CYP2C8, and mifepristone inhibits CYP3A4. Exposure may rise, but dabrafenib also induces CYP3A4 and may lower mifepristone levels, so net effects are unpredictable.
What this interaction means in plain words
Dabrafenib and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabrafenib belongs to Oncology; Mifepristone belongs to Endocrine.
Why it happens
Mifepristone inhibits CYP3A4 metabolism of dabrafenib, while dabrafenib induces CYP3A4 and may reduce mifepristone exposure.
What to do
Monitor for dabrafenib adverse effects such as pyrexia and skin toxicity and for loss of mifepristone effect. Adjust the dabrafenib dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Mifepristone?
MediHelp rates the interaction as moderate. Dabrafenib and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib is metabolized by CYP3A4 and CYP2C8, and mifepristone inhibits CYP3A4. Exposure may rise, but dabrafenib also induces CYP3A4 and may lower mifepristone levels, so net effects are unpredictable.
How serious is the interaction between Dabrafenib and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dabrafenib adverse effects such as pyrexia and skin toxicity and for loss of mifepristone effect. Adjust the dabrafenib dose if toxicity occurs.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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