Drug interactions
Dabrafenib + Nicardipine
Severity: Moderate
Dabrafenib and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine may modestly raise dabrafenib exposure through CYP3A4 inhibition. Higher exposure may increase pyrexia, rash and other dabrafenib toxicities.
What this interaction means in plain words
Dabrafenib and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabrafenib belongs to Oncology; Nicardipine belongs to Cardiovascular.
Why it happens
CYP3A4 inhibition by nicardipine decreases dabrafenib metabolism.
What to do
Monitor for dabrafenib toxicity such as fever and skin reactions, and adjust the dose per labeling if it occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dabrafenib and Nicardipine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Nicardipine
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Nicardipine?
MediHelp rates the interaction as moderate. Dabrafenib and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nicardipine may modestly raise dabrafenib exposure through CYP3A4 inhibition. Higher exposure may increase pyrexia, rash and other dabrafenib toxicities.
How serious is the interaction between Dabrafenib and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dabrafenib toxicity such as fever and skin reactions, and adjust the dose per labeling if it occurs.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
