Drug interactions
Dabrafenib + Nimodipine
Severity: Moderate
Dabrafenib and Nimodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and may substantially reduce nimodipine exposure, risking loss of effect.
What this interaction means in plain words
Dabrafenib and Nimodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabrafenib belongs to Oncology; Nimodipine belongs to Cardiovascular.
Why it happens
Dabrafenib induces CYP3A4, accelerating nimodipine clearance.
What to do
Monitor therapeutic response and blood pressure, and adjust nimodipine dose or choose an alternative if effect is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nimodipine
- Apalutamide + Nimodipine Major
- Carbamazepine + Nimodipine Major
- Ceritinib + Nimodipine Major
- Clarithromycin + Nimodipine Major
- Cobicistat + Nimodipine Major
- Darunavir + Nimodipine Major
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Nimodipine?
MediHelp rates the interaction as moderate. Dabrafenib and Nimodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib induces CYP3A4 and may substantially reduce nimodipine exposure, risking loss of effect.
How serious is the interaction between Dabrafenib and Nimodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor therapeutic response and blood pressure, and adjust nimodipine dose or choose an alternative if effect is inadequate.
What other medicines interact with Nimodipine?
MediHelp also lists interactions of Nimodipine with, for example, Apalutamide, Carbamazepine, Ceritinib. The full list is on the Nimodipine page.
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