Drug interactions
Dabrafenib + Paclitaxel
Severity: Moderate
Dabrafenib and Paclitaxel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and CYP2C8, both involved in paclitaxel clearance, and may lower paclitaxel exposure. This could reduce efficacy.
What this interaction means in plain words
Dabrafenib and Paclitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabrafenib belongs to Oncology; Paclitaxel belongs to Oncology.
Why it happens
Dabrafenib induces CYP3A4 and CYP2C8, accelerating paclitaxel metabolism.
What to do
Monitor treatment response and consider an alternative if loss of efficacy is suspected. Review paclitaxel dosing with the oncology team.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paclitaxel
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Paclitaxel?
MediHelp rates the interaction as moderate. Dabrafenib and Paclitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib induces CYP3A4 and CYP2C8, both involved in paclitaxel clearance, and may lower paclitaxel exposure. This could reduce efficacy.
How serious is the interaction between Dabrafenib and Paclitaxel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor treatment response and consider an alternative if loss of efficacy is suspected. Review paclitaxel dosing with the oncology team.
What other medicines interact with Paclitaxel?
MediHelp also lists interactions of Paclitaxel with, for example, Adenovirus types 4 and 7 live, Cobicistat, Cyclosporine. The full list is on the Paclitaxel page.
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