Drug interactions
Dabrafenib + Primaquine
Severity: Moderate
Dabrafenib and Primaquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and other enzymes and may lower primaquine exposure. This could reduce antimalarial efficacy, although primaquine has multiple metabolic pathways.
What this interaction means in plain words
Dabrafenib and Primaquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabrafenib belongs to Oncology; Primaquine belongs to Anti Parasitic.
Why it happens
Enzyme induction by dabrafenib increases primaquine metabolism.
What to do
Monitor for reduced antimalarial efficacy and consider an alternative or adjusted regimen if response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Primaquine
- Pimozide + Primaquine Contraindicated
- Amiodarone + Primaquine Major
- Amisulpride + Primaquine Major
- Anagrelide + Primaquine Major
- Arsenic trioxide + Primaquine Major
- Asenapine + Primaquine Major
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Primaquine?
MediHelp rates the interaction as moderate. Dabrafenib and Primaquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib induces CYP3A4 and other enzymes and may lower primaquine exposure. This could reduce antimalarial efficacy, although primaquine has multiple metabolic pathways.
How serious is the interaction between Dabrafenib and Primaquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced antimalarial efficacy and consider an alternative or adjusted regimen if response is inadequate.
What other medicines interact with Primaquine?
MediHelp also lists interactions of Primaquine with, for example, Pimozide, Amiodarone, Amisulpride. The full list is on the Primaquine page.
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