Drug interactions
Dabrafenib + Quetiapine
Severity: Moderate
Dabrafenib and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and can lower quetiapine concentrations, possibly leading to loss of psychiatric control. The effect develops over days to weeks.
What this interaction means in plain words
Dabrafenib and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabrafenib belongs to Oncology; Quetiapine belongs to Central Nervous System.
Why it happens
CYP3A4 induction by dabrafenib increases quetiapine clearance.
What to do
Monitor for loss of efficacy and increase the quetiapine dose if needed. Reassess the dose after dabrafenib is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Quetiapine?
MediHelp rates the interaction as moderate. Dabrafenib and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib induces CYP3A4 and can lower quetiapine concentrations, possibly leading to loss of psychiatric control. The effect develops over days to weeks.
How serious is the interaction between Dabrafenib and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of efficacy and increase the quetiapine dose if needed. Reassess the dose after dabrafenib is stopped.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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