Drug interactions
Dabrafenib + Repaglinide
Severity: Moderate
Dabrafenib and Repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and CYP2C8 and may reduce repaglinide concentrations. This can lead to loss of glycemic control.
What this interaction means in plain words
Dabrafenib and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabrafenib belongs to Oncology; Repaglinide belongs to Endocrine.
Why it happens
Enzyme induction increases repaglinide metabolism.
What to do
Monitor blood glucose after dabrafenib is started or stopped and adjust the repaglinide dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporine + Repaglinide Major
- Cyclosporin + Repaglinide Major
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Repaglinide?
MediHelp rates the interaction as moderate. Dabrafenib and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib induces CYP3A4 and CYP2C8 and may reduce repaglinide concentrations. This can lead to loss of glycemic control.
How serious is the interaction between Dabrafenib and Repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after dabrafenib is started or stopped and adjust the repaglinide dose accordingly.
What other medicines interact with Repaglinide?
MediHelp also lists interactions of Repaglinide with, for example, Gemfibrozil, Clarithromycin, Clopidogrel. The full list is on the Repaglinide page.
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