Drug interactions
Dabrafenib + Roflumilast
Severity: Moderate
Dabrafenib and Roflumilast: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and CYP2C9, which can reduce exposure to roflumilast and its active metabolite. This may reduce control of COPD exacerbations.
What this interaction means in plain words
Dabrafenib and Roflumilast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabrafenib belongs to Oncology; Roflumilast belongs to Respiratory.
Why it happens
Dabrafenib induces CYP3A4 and CYP1A2-related metabolism, increasing roflumilast clearance.
What to do
Monitor for reduced roflumilast efficacy and consider alternative COPD therapy if control worsens. Roflumilast labeling advises against use with strong inducers.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Roflumilast
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Roflumilast?
MediHelp rates the interaction as moderate. Dabrafenib and Roflumilast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib induces CYP3A4 and CYP2C9, which can reduce exposure to roflumilast and its active metabolite. This may reduce control of COPD exacerbations.
How serious is the interaction between Dabrafenib and Roflumilast?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced roflumilast efficacy and consider alternative COPD therapy if control worsens. Roflumilast labeling advises against use with strong inducers.
What other medicines interact with Roflumilast?
MediHelp also lists interactions of Roflumilast with, for example, Apalutamide, Carbamazepine, Efavirenz. The full list is on the Roflumilast page.
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