Drug interactions
Dabrafenib + Secobarbital
Severity: Major
Dabrafenib and Secobarbital: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Secobarbital may reduce dabrafenib exposure and compromise its efficacy. Dabrafenib itself is an inducer, so effects on the barbiturate and other drugs can also be complex.
What this interaction means in plain words
Dabrafenib and Secobarbital can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dabrafenib belongs to Oncology; Secobarbital belongs to Central Nervous System.
Why it happens
Barbiturate induction of CYP3A4 and CYP2C8 increases dabrafenib metabolism.
What to do
Avoid combination where possible and use a non-inducing hypnotic. Monitor tumor response if it cannot be avoided.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Secobarbital?
MediHelp rates the interaction as major. Dabrafenib and Secobarbital can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Secobarbital may reduce dabrafenib exposure and compromise its efficacy. Dabrafenib itself is an inducer, so effects on the barbiturate and other drugs can also be complex.
How serious is the interaction between Dabrafenib and Secobarbital?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combination where possible and use a non-inducing hypnotic. Monitor tumor response if it cannot be avoided.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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