Drug interactions
Dabrafenib + Simvastatin
Severity: Moderate
Dabrafenib and Simvastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib can lower simvastatin concentrations, potentially reducing its lipid-lowering efficacy. The effect develops over days to weeks as induction builds and fades after dabrafenib is stopped.
What this interaction means in plain words
Dabrafenib and Simvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabrafenib belongs to Oncology; Simvastatin belongs to Cardiovascular.
Why it happens
Dabrafenib induces CYP3A4, increasing simvastatin metabolism.
What to do
Monitor LDL cholesterol and raise the simvastatin dose if needed, or use a statin not metabolised by CYP3A4. Reassess the dose when dabrafenib is discontinued.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Simvastatin
- Atazanavir + Simvastatin Contraindicated
- Clarithromycin + Simvastatin Contraindicated
- Cobicistat + Simvastatin Contraindicated
- Cyclosporine + Simvastatin Contraindicated
- Cyclosporin + Simvastatin Contraindicated
- Danazol + Simvastatin Contraindicated
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Simvastatin?
MediHelp rates the interaction as moderate. Dabrafenib and Simvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib can lower simvastatin concentrations, potentially reducing its lipid-lowering efficacy. The effect develops over days to weeks as induction builds and fades after dabrafenib is stopped.
How serious is the interaction between Dabrafenib and Simvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor LDL cholesterol and raise the simvastatin dose if needed, or use a statin not metabolised by CYP3A4. Reassess the dose when dabrafenib is discontinued.
What other medicines interact with Simvastatin?
MediHelp also lists interactions of Simvastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Simvastatin page.
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