Drug interactions
Danazol + Simvastatin
Severity: Contraindicated
Danazol and Simvastatin: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol increases simvastatin exposure and has been associated with myopathy and rhabdomyolysis when combined with it. The labeling lists this pairing as contraindicated.
What this interaction means in plain words
Danazol and Simvastatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Danazol inhibits CYP3A4 and so reduces the metabolism of simvastatin, increasing systemic exposure.
What to do
Avoid the combination; if danazol is required, stop simvastatin or switch to a statin not dependent on CYP3A4. Report any unexplained muscle pain or weakness promptly.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Simvastatin
- Atazanavir + Simvastatin Contraindicated
- Clarithromycin + Simvastatin Contraindicated
- Cobicistat + Simvastatin Contraindicated
- Cyclosporine + Simvastatin Contraindicated
- Cyclosporin + Simvastatin Contraindicated
- Darunavir + Simvastatin Contraindicated
Frequently asked questions
Can I take Danazol with Simvastatin?
MediHelp rates the interaction as contraindicated. Danazol and Simvastatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Danazol increases simvastatin exposure and has been associated with myopathy and rhabdomyolysis when combined with it. The labeling lists this pairing as contraindicated.
How serious is the interaction between Danazol and Simvastatin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; if danazol is required, stop simvastatin or switch to a statin not dependent on CYP3A4. Report any unexplained muscle pain or weakness promptly.
What other medicines interact with Simvastatin?
MediHelp also lists interactions of Simvastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Simvastatin page.
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