Drug interactions
clarithromycin + simvastatin
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Rhabdomyolysis risk; contraindicated.
Mechanism of action
Strong CYP3A4 inhibition → ↑ statin.
Clinical management
Hold statin or use non-CYP3A statin (pravastatin/rosuvastatin).
Drug reference
References
Frequently asked questions
Can I take clarithromycin with simvastatin?
The interaction is rated: Contraindicated. Rhabdomyolysis risk; contraindicated.
How serious is the interaction between clarithromycin and simvastatin?
The interaction is rated: Contraindicated. Evidence level: High.
How is the interaction between clarithromycin and simvastatin managed?
Hold statin or use non-CYP3A statin (pravastatin/rosuvastatin).
Why do clarithromycin and simvastatin interact?
Strong CYP3A4 inhibition → ↑ statin.
Full monographs, dosing and an interaction checker in the MediHelp app
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