Drug interactions
Dabrafenib + Terbinafine
Severity: Moderate
Dabrafenib and Terbinafine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and CYP2C9 and may lower terbinafine concentrations. Reduced exposure may weaken antifungal efficacy.
What this interaction means in plain words
Dabrafenib and Terbinafine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabrafenib belongs to Oncology; Terbinafine belongs to Anti Fungals.
Why it happens
Dabrafenib induces CYP3A4 and other CYP enzymes, increasing terbinafine clearance.
What to do
Monitor for lack of antifungal response and extend or change therapy if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Terbinafine
- Terbinafine + Thioridazine Contraindicated
- Desipramine + Terbinafine Major
- Eliglustat + Terbinafine Major
- Flecainide + Terbinafine Major
- Imipramine + Terbinafine Major
- Maprotiline + Terbinafine Major
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Terbinafine?
MediHelp rates the interaction as moderate. Dabrafenib and Terbinafine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib induces CYP3A4 and CYP2C9 and may lower terbinafine concentrations. Reduced exposure may weaken antifungal efficacy.
How serious is the interaction between Dabrafenib and Terbinafine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for lack of antifungal response and extend or change therapy if needed.
What other medicines interact with Terbinafine?
MediHelp also lists interactions of Terbinafine with, for example, Thioridazine, Desipramine, Eliglustat. The full list is on the Terbinafine page.
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