Drug interactions
Dabrafenib + Ticagrelor
Severity: Major
Dabrafenib and Ticagrelor: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and may reduce ticagrelor exposure, weakening its antiplatelet effect. Loss of efficacy may increase ischemic risk in patients with recent stent or acute coronary syndrome.
What this interaction means in plain words
Dabrafenib and Ticagrelor can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dabrafenib belongs to Oncology; Ticagrelor belongs to Cardiovascular.
Why it happens
Dabrafenib induces CYP3A4, accelerating ticagrelor metabolism.
What to do
Avoid concomitant use if possible and consider an alternative antiplatelet strategy. If unavoidable, monitor for ischemic events.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dabrafenib and Ticagrelor, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Ticagrelor
- Itraconazole + Ticagrelor Contraindicated
- Ketoconazole + Ticagrelor Contraindicated
- Levoketoconazole + Ticagrelor Contraindicated
- Abciximab + Ticagrelor Major
- Abrocitinib + Ticagrelor Major
- Acalabrutinib + Ticagrelor Major
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Ticagrelor?
MediHelp rates the interaction as major. Dabrafenib and Ticagrelor can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dabrafenib induces CYP3A4 and may reduce ticagrelor exposure, weakening its antiplatelet effect. Loss of efficacy may increase ischemic risk in patients with recent stent or acute coronary syndrome.
How serious is the interaction between Dabrafenib and Ticagrelor?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use if possible and consider an alternative antiplatelet strategy. If unavoidable, monitor for ischemic events.
What other medicines interact with Ticagrelor?
MediHelp also lists interactions of Ticagrelor with, for example, Itraconazole, Ketoconazole, Levoketoconazole. The full list is on the Ticagrelor page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
