Drug interactions
Dabrafenib + Tinidazole
Severity: Moderate
Dabrafenib and Tinidazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib is a CYP3A4 inducer and may lower tinidazole exposure, since tinidazole is partly metabolized by CYP3A4. Reduced concentrations could lessen antimicrobial efficacy, particularly in single-dose regimens.
What this interaction means in plain words
Dabrafenib and Tinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabrafenib belongs to Oncology; Tinidazole belongs to Anti Parasitic.
Why it happens
Induction of CYP3A4 by dabrafenib increases tinidazole clearance.
What to do
Monitor for clinical response to tinidazole and consider an alternative antimicrobial if treatment failure is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tinidazole
- Disulfiram + Tinidazole Contraindicated
- Ethanol + Tinidazole Major
- Fexinidazole + Tinidazole Major
- Lopinavir + Tinidazole Major
- Nilotinib + Tinidazole Major
- Ritonavir + Tinidazole Major
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Tinidazole?
MediHelp rates the interaction as moderate. Dabrafenib and Tinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib is a CYP3A4 inducer and may lower tinidazole exposure, since tinidazole is partly metabolized by CYP3A4. Reduced concentrations could lessen antimicrobial efficacy, particularly in single-dose regimens.
How serious is the interaction between Dabrafenib and Tinidazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for clinical response to tinidazole and consider an alternative antimicrobial if treatment failure is suspected.
What other medicines interact with Tinidazole?
MediHelp also lists interactions of Tinidazole with, for example, Disulfiram, Ethanol, Fexinidazole. The full list is on the Tinidazole page.
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