Drug interactions
Dabrafenib + Vinblastine
Severity: Moderate
Dabrafenib and Vinblastine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and may reduce vinblastine exposure. This could lessen antitumor efficacy, though clinical data are limited.
What this interaction means in plain words
Dabrafenib and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabrafenib belongs to Oncology; Vinblastine belongs to Oncology.
Why it happens
CYP3A4 induction by dabrafenib increases vinblastine metabolism.
What to do
Monitor tumor response to vinblastine. Consider dose reassessment if response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vinblastine
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Vinblastine?
MediHelp rates the interaction as moderate. Dabrafenib and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib induces CYP3A4 and may reduce vinblastine exposure. This could lessen antitumor efficacy, though clinical data are limited.
How serious is the interaction between Dabrafenib and Vinblastine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tumor response to vinblastine. Consider dose reassessment if response is inadequate.
What other medicines interact with Vinblastine?
MediHelp also lists interactions of Vinblastine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vinblastine page.
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