Drug interactions
Dacarbazine + Trastuzumab deruxtecan
Severity: Major
Dacarbazine and Trastuzumab deruxtecan: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trastuzumab deruxtecan frequently causes neutropenia, and combining it with myelosuppressive dacarbazine can raise the risk of severe or febrile neutropenia and infection.
What this interaction means in plain words
Dacarbazine and Trastuzumab deruxtecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dacarbazine belongs to Oncology; Trastuzumab deruxtecan belongs to Oncology.
Why it happens
Additive myelosuppression from cytotoxic payload and alkylating chemotherapy.
What to do
Monitor blood counts before each dose and hold or reduce doses per labeled neutropenia criteria. Advise patients to report fever promptly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dacarbazine
Other interactions of Trastuzumab deruxtecan
Frequently asked questions
Can I take Dacarbazine with Trastuzumab deruxtecan?
MediHelp rates the interaction as major. Dacarbazine and Trastuzumab deruxtecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Trastuzumab deruxtecan frequently causes neutropenia, and combining it with myelosuppressive dacarbazine can raise the risk of severe or febrile neutropenia and infection.
How serious is the interaction between Dacarbazine and Trastuzumab deruxtecan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts before each dose and hold or reduce doses per labeled neutropenia criteria. Advise patients to report fever promptly.
What other medicines interact with Dacarbazine?
MediHelp also lists interactions of Dacarbazine with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Dacarbazine page.
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