Drug interactions
Bleomycin + Trastuzumab deruxtecan
Severity: Major
Bleomycin and Trastuzumab deruxtecan: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trastuzumab deruxtecan causes neutropenia and interstitial lung disease, and bleomycin carries a risk of pulmonary toxicity and some myelosuppression. Combining them may increase infection risk and lung injury.
What this interaction means in plain words
Bleomycin and Trastuzumab deruxtecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bleomycin belongs to Oncology; Trastuzumab deruxtecan belongs to Oncology.
Why it happens
Additive myelosuppression and overlapping pulmonary toxicity.
What to do
Monitor blood counts and respiratory symptoms closely, and evaluate promptly any new cough or dyspnea. Avoid the combination where alternatives exist.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Bleomycin and Trastuzumab deruxtecan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Bleomycin
- Adenovirus types 4 and 7 live + Bleomycin Contraindicated
- Bleomycin + Brentuximab Contraindicated
- Bleomycin + Brentuximab vedotin Contraindicated
- Bleomycin + Dengue vaccine Major
- Bleomycin + Cholera vaccine Moderate
- Bleomycin + Ethotoin Moderate
Other interactions of Trastuzumab deruxtecan
Frequently asked questions
Can I take Bleomycin with Trastuzumab deruxtecan?
MediHelp rates the interaction as major. Bleomycin and Trastuzumab deruxtecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Trastuzumab deruxtecan causes neutropenia and interstitial lung disease, and bleomycin carries a risk of pulmonary toxicity and some myelosuppression. Combining them may increase infection risk and lung injury.
How serious is the interaction between Bleomycin and Trastuzumab deruxtecan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and respiratory symptoms closely, and evaluate promptly any new cough or dyspnea. Avoid the combination where alternatives exist.
What other medicines interact with Bleomycin?
MediHelp also lists interactions of Bleomycin with, for example, Adenovirus types 4 and 7 live, Brentuximab, Brentuximab vedotin. The full list is on the Bleomycin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
