Drug interactions
Dactinomycin + Doxorubicin liposomal
Severity: Moderate
Dactinomycin and Doxorubicin liposomal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Giving an anthracycline together with dactinomycin can cause radiation recall reactions, including pneumonitis, in tissue that was previously irradiated. This has been described in children and can appear at variable times after the radiotherapy. The reaction may be severe and needs prompt recognition.
What this interaction means in plain words
Dactinomycin and Doxorubicin liposomal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Both agents are radiosensitizing and can reactivate latent radiation-induced tissue injury, causing a recall reaction.
What to do
Review prior radiation fields before starting the combination and monitor for cough, dyspnea or hypoxia. If pneumonitis is suspected, hold the drugs and evaluate for treatment with corticosteroids.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dactinomycin
- Adenovirus types 4 and 7 live + Dactinomycin Contraindicated
- Belatacept + Dactinomycin Major
- Dactinomycin + Dengue vaccine Major
- Dactinomycin + Etrasimod Major
- Dactinomycin + Fingolimod Major
- Dactinomycin + Palifermin Major
Frequently asked questions
Can I take Dactinomycin with Doxorubicin liposomal?
MediHelp rates the interaction as moderate. Dactinomycin and Doxorubicin liposomal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Giving an anthracycline together with dactinomycin can cause radiation recall reactions, including pneumonitis, in tissue that was previously irradiated. This has been described in children and can appear at variable times after the radiotherapy. The reaction may be severe and needs prompt recognition.
How serious is the interaction between Dactinomycin and Doxorubicin liposomal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review prior radiation fields before starting the combination and monitor for cough, dyspnea or hypoxia. If pneumonitis is suspected, hold the drugs and evaluate for treatment with corticosteroids.
What other medicines interact with Dactinomycin?
MediHelp also lists interactions of Dactinomycin with, for example, Adenovirus types 4 and 7 live, Belatacept, Dengue vaccine. The full list is on the Dactinomycin page.
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