Drug interactions
Dactinomycin + Etrasimod
Severity: Major
Dactinomycin and Etrasimod: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etrasimod lowers circulating lymphocytes, and dactinomycin is a cytotoxic, myelosuppressive agent. Together they may produce additive immunosuppression and a higher risk of serious infection. The combination has not been formally studied, and the effect of etrasimod on immune function can persist for some weeks after it is stopped.
What this interaction means in plain words
Dactinomycin and Etrasimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dactinomycin belongs to Oncology; Etrasimod belongs to Gastrointestinal Tract.
Why it happens
Additive immunosuppression from S1P receptor modulation (lymphocyte sequestration) plus cytotoxic myelosuppression.
What to do
Avoid the combination where possible, and if it is necessary, monitor closely for infection and check blood counts regularly. Allow for the prolonged immune effect of etrasimod after discontinuation when sequencing therapies.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dactinomycin and Etrasimod, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Dactinomycin
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Dactinomycin with Etrasimod?
MediHelp rates the interaction as major. Dactinomycin and Etrasimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Etrasimod lowers circulating lymphocytes, and dactinomycin is a cytotoxic, myelosuppressive agent. Together they may produce additive immunosuppression and a higher risk of serious infection. The combination has not been formally studied, and the effect of etrasimod on immune function can persist for some weeks after it is stopped.
How serious is the interaction between Dactinomycin and Etrasimod?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, and if it is necessary, monitor closely for infection and check blood counts regularly. Allow for the prolonged immune effect of etrasimod after discontinuation when sequencing therapies.
What other medicines interact with Dactinomycin?
MediHelp also lists interactions of Dactinomycin with, for example, Adenovirus types 4 and 7 live, Belatacept, Dengue vaccine. The full list is on the Dactinomycin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
